.

sIBM and viruses.

.

.

To begin with, human biological systems are extraordinarily complex. Diseases like cancer are extraordinarily complex. Based on my reading, I think that sporadic inclusion body myositis is every bit as complicated as cancer. The issue of viruses as they relate to the myositis illnesses is an illustration of this complexity.

Over the years, a number of viruses have been implicated in sporadic inclusion body myositis as illustrated by this 2017 article. However, these are very scattered cases and it is far from clear that any given virus is related to causing sporadic inclusion body myositis. Clearly, no definitive link has been found between viruses and these illnesses, however it is hard to explain or account for these rare cases of sporadic inclusion body myositis associated with different viruses if these cases are more than coincidental.

Another complicated issue with viruses is what is called human endogenous retroviruses (HERVs). Endogenous means caused from inside. Retroviruses are a type of virus that incorporates itself into the DNA of the person it infects. Over the hundreds of thousands of years of human existence, these viruses have incorporated themselves into our DNA. Today, about 8 percent of our DNA is made up of these viruses. Normally, these viruses are dormant and do not cause any trouble but, one theory is that, in some conditions, these viruses can somehow reactivate and cause illnesses. The following article by Gruchot (2019), shows how these viruses might be related to multiple sclerosis. Today, it's an interesting question to consider if this kind of virus (HERVs) could be somehow implicated in sporadic inclusion body myositis.

.